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Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity
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STEP 1 (NEJM 2021) showed that semaglutide 2.4 mg once weekly produced a mean weight loss of 14.9% in 1,961 adults with obesity — with 1 in 3 participants losing over 20%
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New in the May 29, 2025, issue of NEJM: Sotatercept in Pulmonary Arterial Hypertension (ZENITH phase 3 trial) https://nej.md/4iYkLbj Oral Semaglutide and Cardiovascular Outcomes (SOUL trial) https://nej.md/4hHII5M Upadacitinib for Giant-Cell Arteritis
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2. Original Article: Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes https://t.co/sHpHQFOGLu #Cardiology
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SELECT Trial
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NEJM: Once-Weekly Semaglutide in Adults with Overweight or Obesity : r/medicine
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LEADER (NEJM 2016) was the landmark CVOT for liraglutide in T2DM. In 9,340 patients at high cardiovascular risk, liraglutide reduced 3-point MACE by 13% (HR 0.87; p=0.01) and cardiovascular death by 22% (
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