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tirzepatide articles A first-in-human study suggested that tirzepatide — a dual GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist — modulated abnormal activity in the brain's nucleus accumbens, thereby reducing food cravings and inducing

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Finngirl
Grantham, US
★★★★★ 5
Good quality, smooth feel
I got these briefs so recently that have washed just one pair so far. First off, these are very comfortable, the material is soft & bordering silky, good quality sewing. Wash well and minimal if any shrinkage. They do come a bit wrinkled from the dryer but hey, these are underwear and will go on smoothly. If it were a t-shirt, I would look sloppy. I feel the sizing is accurate. No rolling and these don't announce themselves under clothing. Planning on getting more of these boxers and replacing my old panties.
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Reviewed in the United States on January 31, 2026
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Skurtzo
Boise, US
★★★★★ 4
A little snug on the thighs
Size: Medium, Color: Multicoloured G (5-pack)
Super comfy, soft and thin. For reference, I'm 5'6", 135, athletic build. I bought medium. I almost returned them because I thought they were a bit too snug on my thighs, and my thighs are not large at all. I was concerned about panty lines under snug clothing. But, because they're thin, I figured they would probably stretch, so I kept them. So far, I've only worn them under a night shirt, but they're super comfortable and they dont ride up at all. Very nice, but if your thighs are a little thick, you probably won't like them.
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Reviewed in the United States on August 29, 2025
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Shanna
Pawtucket, US
★★★★★ 5
Functional + Sexy
Size: Small, Color: Multicoloured E-(5-pack), Size: Small, Color: Multicoloured E-(5-pack)
Not only do these feel good, my husband can’t keep his hands off me. They fit so good and are soft. I change into these to sleep but also just use them as shorts to wear around the house. They’re comfortable and don’t slide around. I got a size small and I’m 100lbs.
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Reviewed in the United States on April 13, 2026
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ClairY
Battle Creek, US
★★★★★ 5
Finally!
Size: X-Large, Color: All Black D (5-pack)
Finally, comfortable underwear that don’t end up giving me a wedgie. I have a round booty and most cuts of underwear end up shifting as I walk and sit. The hem of the underwear comes right under my cheeks and the lightweight material ensures there’s no panty line and no shifting to where I don’t want them! I’m definitely purchasing more.
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Reviewed in the United States on May 17, 2026
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Amazon Customer
West Palm Beach, US
★★★★★ 3
Ehh
Size: Medium, Color: Multicoloured E-(5-pack)
Very thin, still comfy but very thin material. Super soft though. I've worn and washed and they have held up but I won't be repurchasing bc these are so thin
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Reviewed in the United States on April 14, 2026

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